✨ CIRCADIA Serum 71 Renewal Serum is a multi-mechanism brightening serum built for clients presenting with overlapping concerns — hyperpigmentation, post-breakout discoloration, redness, and early texture loss — where a single well-formulated step outperforms stacking multiple actives.

The formula centers on tranexamic acid, mandelic acid, and azelaic acid working through complementary pathways: interrupting melanin transfer, accelerating surface turnover, and normalizing the enzymatic drivers of excess pigmentation. Mandelic acid's larger molecular size makes this a genuine option for sensitive and darker skin tones that can't tolerate glycolic or lactic acid — the exfoliation is real, and so is the tolerability. CM-Glucan Forte adds barrier and calming support to offset the actives, while Copper Lysinate/Prolinate addresses the firmness dimension often absent from brightening-only formulas.

This serum travels naturally from treatment room to home-care prescription, reinforcing in-clinic brightening results and extending service value between appointments.

A strong retail anchor for clients in active brightening or resurfacing protocols.

• Visible reduction in dark spots and hyperpigmentation: Tranexamic acid disrupts melanin transfer pathways, while mandelic acid accelerates surface cell turnover and azelaic acid inhibits excess melanin production — together delivering a multi-mechanism approach to fading the appearance of dark spots, post-breakout marks, and areas of uneven pigmentation.
• Gentler exfoliation for smoother, more refined texture: Mandelic acid's larger molecular structure slows its absorption rate relative to smaller AHAs, delivering surface exfoliation and texture refinement with a reduced risk of irritation — making this serum suitable for sensitive and reactive skin types that may not tolerate glycolic or lactic acid well.
• Calmed appearance of redness and blotchiness: Azelaic acid helps normalize surface irregularities associated with redness and uneven tone, while CM-Glucan Forte supports the skin's natural defense response to help the skin's surface appear calmer and more balanced.
• Barrier support alongside active exfoliation: CM-Glucan Forte (Magnesium Carboxymethyl Beta-Glucan) activates surface immune cells to support the skin's natural recovery and barrier function — a meaningful counterbalance to the exfoliating and brightening actives in the formula that helps the skin maintain resilience during treatment.
• Improved appearance of firmness and skin density: Copper Lysinate/Prolinate delivers bioavailable copper ions that support the enzymatic processes underlying structural protein cross-linking, contributing to the appearance of firmer, denser skin and addressing visible loss of elasticity.
• Comprehensive tone correction for multiple skin concerns: The combination of tranexamic acid, mandelic acid, and azelaic acid addresses hyperpigmentation, acne-related discoloration, redness, and uneven texture through complementary and non-redundant mechanisms — delivering a broad tone-correcting effect within a single serum step.

Tranexamic Acid: A synthetic amino acid derivative that interrupts melanin transfer pathways in the skin, helping to visibly reduce the appearance of dark spots, post-inflammatory discoloration, and uneven tone. Works without the irritation associated with stronger brightening actives, making it well suited to sensitive and reactive skin profiles.

Mandelic Acid: An alpha-hydroxy acid derived from bitter almonds. Its larger molecular size slows skin penetration compared to glycolic acid, producing a gentler exfoliating action that refines surface texture and supports more even tone with reduced risk of irritation — an important advantage for sensitive and darker skin tones.

Azelaic Acid: A dicarboxylic acid with well-established activity against the enzyme tyrosinase, which drives excess melanin production. Concurrently helps normalize follicular keratinization and reduces the appearance of redness and blotchiness, addressing both acne-related discoloration and tone irregularities in a single active.

Magnesium Carboxymethyl Beta-Glucan - known as CM-Glucan Forte: A stabilized, water-soluble form of beta-glucan derived from oat or yeast cell walls. Beta-glucans are recognized for activating cutaneous defense cells (Langerhans cells and macrophages), supporting the skin's natural recovery processes. In this formula, CM-Glucan Forte acts as a calming and barrier-supportive counterbalance to the exfoliating and brightening actives present in the serum.

Copper Lysinate/Prolinate: A copper-chelated amino acid complex (copper peptide analog) that delivers copper ions in a skin-compatible carrier. Copper is a cofactor required for the activity of lysyl oxidase and other enzymes involved in structural protein cross-linking, supporting the appearance of firmer, denser skin over time. Complements the texture-refining action of the acids by addressing the loss-of-firmness dimension of aging.

1. Ensure the client's face has been thoroughly cleansed and is free of residual makeup, sunscreen, or other product.
2. Dispense several drops of the serum onto fingertips.
3. Smooth the serum evenly over the face and neck using gentle, upward strokes.
4. Avoid the immediate eye area during application.
5. Allow the serum to absorb fully before proceeding to the next step.
6. Follow immediately with a moisturizer or corrective lotion to seal the treatment and support barrier function.
7. Use in the evening as part of the client's professional treatment or as a home-care prescription for nightly use.

Layering and client selection notes

Because this serum combines an AHA (mandelic acid), tranexamic acid, and azelaic acid in a single formula, it is well positioned for clients presenting with overlapping concerns — hyperpigmentation alongside acne or sensitivity — where a single multi-mechanism serum reduces protocol complexity. For clients new to acid-based serums or with highly reactive skin, consider introducing the product every other evening initially before building to nightly use, as the AHA component may cause mild adjustment-period sensitivity. This serum is a strong retail candidate for clients completing in-clinic brightening or resurfacing treatments: the at-home continuation of active-acid brightening reinforces in-clinic results and supports treatment revenue between appointments. Daily broad-spectrum SPF is essential for any client using an AHA-containing leave-on serum to prevent UV-driven re-pigmentation from undoing the brightening effect.