✨ A biotech-forward evening lotion from CIRCADIA built for clients with aging, dull, or retinoid-intolerant skin — where firming and radiance work needs a vitamin A alternative.

At its core, EUK-134 delivers enzyme-mimic antioxidant protection that conventional antioxidants can't replicate, neutralizing reactive oxygen species at the source. Pepha-ctive microalgae extract supports cellular energy metabolism, addressing the fatigued, lackluster look common in mature and post-treatment skin. A dual-peptide system — Acetyl Tetrapeptide-2 and Palmitoyl Tripeptide-38 — reinforces the skin's natural renewal signaling for a visibly firmer, more resilient appearance over time, while Vibrio Alginolyticus Ferment Filtrate refines surface texture through a desquamation-support pathway.

💡 For practices offering resurfacing or light-based services, this slots in as a post-treatment retail recommendation once the barrier has stabilized — giving sensitized clients a credible firming protocol without irritation risk.

A natural fit for anti-aging facial menus serving clients who can't tolerate retinoids.

• Antioxidant Protection via Enzyme Mimicry: EUK-134 (Ethylbisiminomethylguaiacol Manganese Chloride) functions as a mimic of the skin's own antioxidant enzymes, converting reactive oxygen species into harmless byproducts. This helps protect the skin's appearance against the visible effects of environmental oxidative stress.
• Radiance Support Through Mitochondrial Energy: Pepha-ctive (Algae Extract) is associated with supporting cellular energy metabolism, contributing to a more radiant, energized-looking complexion — particularly beneficial for dull or fatigued skin.
• Firmer, More Resilient Skin Appearance: Acetyl Tetrapeptide-2 (Thymulen 4), a biomimetic peptide modeled on thymopoietin, works alongside Palmitoyl Tripeptide-38 to support the skin's natural renewal signaling. Together, they contribute to a visibly firmer and more resilient complexion over time.
• Improved Skin Texture and Smoothness: Vibrio Alginolyticus Ferment Filtrate (Exo-T) supports natural skin surface renewal through desquamation and differentiation processes, helping to improve smoothness, refine texture, and support the skin's structural integrity.
• Immediate Surface Softness: Panthenol and Allantoin work together as a conditioning pair above functional concentration to deliver immediate skin softness and a smooth surface feel from the first application.

Ethylbisiminomethylguaiacol Manganese Chloride — known as EUK-134: A synthetic mimic of superoxide dismutase and catalase, two of the skin's own antioxidant enzymes. EUK-134 scavenges superoxide radicals and breaks down hydrogen peroxide, converting reactive oxygen species into water and oxygen. This enzyme-level approach provides comprehensive antioxidant protection that complements and extends beyond conventional antioxidant ingredients.: A synthetic mimic of superoxide dismutase and catalase, two of the skin's own antioxidant enzymes. EUK-134 scavenges superoxide radicals and breaks down hydrogen peroxide, converting reactive oxygen species into water and oxygen. This enzyme-level approach provides comprehensive antioxidant protection that complements and extends beyond conventional antioxidant ingredients.

Algae Extract — known as Pepha-ctive (Microalgae Extract): A microalgae-derived bioactive associated with supporting the skin's energy metabolism. By promoting mitochondrial activity, it helps support a more radiant and energized-looking complexion — particularly relevant for dull or fatigued skin.: A microalgae-derived bioactive associated with supporting the skin's energy metabolism. By promoting mitochondrial activity, it helps support a more radiant and energized-looking complexion — particularly relevant for dull or fatigued skin.

Acetyl Tetrapeptide-2 — known as Thymulen 4: A biomimetic peptide designed to mimic thymopoietin, a protein involved in skin immune and regenerative signaling. It supports the appearance of firmer, more resilient skin by reinforcing the skin's natural renewal processes.: A biomimetic peptide designed to mimic thymopoietin, a protein involved in skin immune and regenerative signaling. Supports the appearance of firmer, more resilient skin by reinforcing the skin's natural renewal processes.

Vibrio Alginolyticus Ferment Filtrate — known as Exo-T: A ferment filtrate derived from microorganisms found in the mineral-rich rims of Polynesian atolls. This exopolysaccharide-rich ingredient supports skin surface renewal by promoting natural desquamation and differentiation, contributing to improved smoothness, texture, and tensile strength.: A ferment filtrate derived from microorganisms found in the mineral-rich rims of Polynesian atolls. This exopolysaccharide-rich ingredient supports skin surface renewal by promoting natural desquamation and differentiation, contributing to improved smoothness, texture, and tensile strength.

Palmitoyl Tripeptide-38: A matrix-stimulating peptide that supports the appearance of plumper, firmer skin by signaling to the skin's surface structure. As a leave-on ingredient at low concentration, it complements the peptide signaling of Acetyl Tetrapeptide-2 via a distinct structural mechanism.: A matrix-stimulating peptide that supports the appearance of plumper, firmer skin by signaling to the skin's surface structure. As a leave-on ingredient, it complements the peptide signaling of Acetyl Tetrapeptide-2 via a distinct structural-conditioning mechanism.

Panthenol / Allantoin — Skin-Conditioning Complex: Two well-established leave-on conditioning agents that together deliver immediate surface comfort. Panthenol (pro-vitamin B5) helps maintain surface hydration and softness; Allantoin supports a smooth, even skin feel. This pairing provides the product's immediate tactile softness while the biotech actives work over time.: Two well-established leave-on conditioning agents that together deliver immediate surface comfort. Panthenol (pro-vitamin B5) helps maintain surface hydration and softness; Allantoin supports a smooth, even skin feel — providing the immediate tactile softness that complements the longer-acting biotech actives in the formula.

1. Use in the evening as the final step after cleansing and any serum application.
2. Dispense 1–2 pumps of the lotion onto clean fingertips.
3. Apply evenly over the client's face and neck using upward, outward strokes.
4. Avoid the immediate eye area during application.
5. Allow the lotion to absorb fully; do not rinse.

Integrating into anti-aging facial protocols

This lotion is formulated around biotech actives that work best when layered after a targeted serum — the serum delivers higher-concentration water-phase actives, and the lotion's leave-on emulsion base locks in hydration while the peptide and enzyme-mimic stack continues to act overnight. For clients who are retinoid-intolerant, sensitized, or in a post-treatment recovery phase, this product provides a strong alternative pathway for addressing firmness and texture without the irritation risk associated with vitamin A derivatives. This makes it an effective retail recommendation following professional resurfacing or light-based services, once the skin's barrier has stabilized.